Zoledronic Acid
Information
- Drug Name
- Zoledronic Acid
- Description
- Entry(CIViC)
- 1
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| salivary gland cancer | ERBB2 OVEREXPRESSION ERBB2 OVEREXPRESSION | C |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 20504363 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Case report of a a 58 year old man with multiple b... | ERBB2 | ERBB2 OVEREXPRESSION ERBB2 OVEREXPRESSION | Sensitivity | true | CIViC Evidence | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02516423 | Active, not recruiting | Phase 3 | Ixazomib Citrate, Lenalidomide, Dexamethasone, and Zoledronic Acid or Zoledronic Acid Alone After Radiation Therapy in Treating Patients With Solitary Plasmacytoma of Bone | December 2015 | |
| NCT03173976 | Active, not recruiting | Phase 1 | Anti-Osteoclast Therapy as Neoadjuvant in Treatment of Chondrosarcoma - Phase 1b Trial | July 18, 2017 | July 1, 2024 |
| NCT05405894 | Active, not recruiting | Efficacy of Zoledronic Acid to Prevent Bone Loss Following Denosumab Discontinuation | September 1, 2022 | July 1, 2025 | |
| NCT00470223 | Active, not recruiting | Phase 3 | Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma | March 2007 | December 2026 |
| NCT00412022 | Active, not recruiting | Phase 3 | HOBOE: A Phase 3 Study of Adjuvant Triptorelin and Tamoxifen, Letrozole, or Letrozole and Zoledronic Acid in Premenopausal Patients With Breast Cancer. | March 2004 | November 2024 |
| NCT00268476 | Active, not recruiting | Phase 2/Phase 3 | Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy | July 8, 2005 | December 2030 |
| NCT05666310 | Active, not recruiting | Phase 4 | Muscle Impact of Treating Osteoporosis | February 14, 2023 | July 1, 2026 |
| NCT04498715 | Active, not recruiting | N/A | Trochanteric Femur Fracture Operated With Dynamic Hip Screw System (DHS) Augmented With a Biphasic Apatite Sulphate Combined With Systemic or Local Bisphosphonate | June 1, 2021 | December 2024 |
| NCT04087096 | Active, not recruiting | Phase 4 | Denosumab to Prevent High-Turnover Bone Loss After Bariatric Surgery | August 24, 2020 | August 2024 |
| NCT00050011 | Completed | Phase 3 | Zoledronic Acid - Letrozole Adjuvant Synergy Trial (ZFAST) - Cancer Treatment Related Bone Loss in Postmenopausal Women With Estrogen Receptor Positive and/or Progesterone Receptor Positive Breast Cancer Receiving Adjuvant Hormonal Therapy | September 2002 | January 2009 |
| NCT00051636 | Completed | Phase 3 | Safety and Efficacy Trial With Zoledronic Acid for the Treatment of Paget's Disease of Bone, Including an Extended Observation Period | January 2001 | April 2011 |
| NCT00060138 | Completed | Phase 1/Phase 2 | Monoclonal Antibody Compared With Zoledronate in Treating Women With Breast Cancer and Bone Metastases | November 2002 | |
| NCT00063479 | Completed | Phase 2 | Bisphosphonate Treatment of Osteogenesis Imperfecta | June 2003 | May 2007 |
| NCT00063609 | Completed | Phase 4 | The Effect of Zoledronic Acid on Bone Loss in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy | April 2003 | April 2005 |
| NCT00079001 | Completed | Phase 3 | Zoledronate in Preventing Skeletal (Bone)-Related Events in Men Who Are Receiving Androgen Deprivation Therapy For Prostate Cancer and Bone Metastases | January 2004 | October 2014 |
| NCT00081159 | Completed | Phase 2 | Hormone Ablation Therapy, Doxorubicin, and Zoledronate With or Without Strontium 89 in Treating Patients With Androgen-Dependent Prostate Cancer and Bone Metastases | July 2004 | September 2014 |
| NCT00086268 | Completed | Phase 3 | Non-small Cell Lung Cancer Study US75 (Z-PACT) | April 2004 | October 2007 |
| NCT00087659 | Completed | N/A | A Prostate Cancer Study in Men Undergoing Androgen Deprivation Therapy | December 2003 | May 2007 |
| NCT00097812 | Completed | Phase 3 | Switching Osteoporosis Patients Currently on Oral Bisphosphonate to Zoledronic Acid | May 2004 | December 2005 |
| NCT00097825 | Completed | Phase 3 | Efficacy and Safety of Zoledronic Acid for the Treatment of Osteoporosis in Men | April 2004 | August 2007 |
| NCT00099541 | Completed | Phase 4 | Non-small Cell Lung Cancer Registry | November 2004 | November 2007 |
| NCT00100555 | Completed | Phase 3 | A Study of the Clinical Safety, Tolerability, and Efficacy of Zoledronic Acid Compared to an Oral Bisphosphonate | June 2004 | June 2005 |
| NCT00100620 | Completed | Phase 3 | Efficacy and Safety of Zoledronic Acid in the Prevention and Treatment of Corticosteroid Induced Osteoporosis | June 2004 | April 2007 |
| NCT00103740 | Completed | Phase 3 | Safety and Efficacy Trial With Zoledronic Acid for the Treatment of Paget's Disease of Bone, Including an Extended Observation Period | April 2002 | April 2011 |
| NCT00104104 | Completed | Phase 4 | A Multiple Myeloma Trial in Patients With Bone Metastases | October 2004 | October 2007 |
| NCT00107263 | Completed | Phase 3 | Zoledronate in Preventing Bone Loss in Postmenopausal Women Who Are Receiving Letrozole for Stage I, Stage II, or Stage IIIA Breast Cancer | January 2005 | August 2012 |
| NCT00114270 | Completed | N/A | Letrozole With or Without Zoledronate in Treating Healthy Postmenopausal Women With High Breast Density | May 2004 | June 2007 |
| NCT00114556 | Completed | Phase 4 | The Effect of Zoledronic Acid on Bone Density in Liver Transplant Patients | February 2000 | August 2004 |
| NCT00127205 | Completed | Phase 3 | S0307 Phase III Trial of Bisphosphonates as Adjuvant Therapy for Primary Breast Cancer. | July 2005 | March 29, 2021 |
| NCT00131118 | Completed | Phase 2 | Zoledronic Acid in Children (1 -17 Years) With Severe Osteogenesis Imperfecta | July 2004 | May 2007 |
| NCT00132808 | Completed | Phase 3 | Zoledronic Acid in the Prevention of Bone Loss in Postmenopausal Women With Osteopenia, 45 Years of Age and Older | July 2004 | February 2008 |
| NCT00145275 | Completed | Phase 3 | To Assess the Efficacy of Over-the-counter Analgesics in the Prevention/Treatment of Transient Post-dose Symptoms Following Zoledronate Infusion in Post-menopausal Women | December 2004 | October 2005 |
| NCT00145327 | Completed | Phase 3 | Double-blind Extension of HORIZON Pivotal Fracture Trial (Zoledronic Acid in the Treatment of Postmenopausal Osteoporosis) | May 2005 | November 2009 |
| NCT00151073 | Completed | Phase 2 | Estramustine, Docetaxel and Zoledronate Treatment in Hormone-Refractory Adenocarcinoma of the Prostate | April 2002 | September 2007 |
| NCT00171314 | Completed | Phase 3 | The Use of Zoledronic Acid to Prevent Cancer-treatment Bone Loss in Post-menopausal Women Receiving Adjuvant Letrozole for Breast Cancer | March 2004 | |
| NCT00171340 | Completed | Phase 3 | Zoledronic Acid in the Prevention of Cancer Treatment Related Bone Loss in Postmenopausal Women Receiving Letrozole for Breast Cancer. | May 2003 | February 2010 |
| NCT00171639 | Completed | Phase 3 | The Use of Zoledronic Acid in Men on Androgen Deprivation Therapy for Prostate Cancer With Preexisting Osteoporosis | June 2004 | March 2007 |
| NCT00172003 | Completed | Phase 4 | Effect of Zoledronic Acid in Patients With Renal Cell Cancer and Bone Metastasis | September 2004 | July 2009 |
| NCT00172016 | Completed | Phase 4 | A Study to Evaluate the Efficacy and Tolerability of Zoledronic Acid in Patients With Metastatic Prostate Cancer Who Can be Treated With a Group of Medications Known as Bisphosphonates | January 2004 | |
| NCT00172029 | Completed | Phase 4 | Study Comparing Full-dose Radiotherapy Versus Reduced Dose in the Management of Bone Metastasis in Patients With Breast Cancer Receiving Zoledronic Acid | April 2003 | |
| NCT00172055 | Completed | Phase 3 | Study to Assess Efficacy and Safety of Zoledronic Acid and the Value of Markers of Bone Resorption in the Prediction of Bone Metastases and Cancer Treatment-induced Bone Loss (CTIBL) in Patients With Prostate Cancer on Hormone Therapy | December 2004 | July 2009 |
| NCT00181584 | Completed | Phase 2 | Zoledronic Acid to Prevent Bone Loss During Androgen Deprivation Therapy for Prostate Cancer | September 2003 | |
| NCT00193856 | Completed | Phase 3 | RADAR Trial - Randomised Androgen Deprivation and Radiotherapy | October 2003 | August 2017 |
| NCT00202059 | Completed | Phase 3 | Effects of Zometa and Physical Activity on Bone Density in Women Receiving Chemotherapy for Breast Cancer | June 2003 | September 2007 |
| NCT00219219 | Completed | Phase 4 | Zoledronic Acid in the Prevention of Skeletal-related Events in Hormone Refractory and Hormone-sensitive Prostate Cancer Patients With Bone Metastases | September 2003 | October 2006 |
| NCT00219258 | Completed | Phase 3 | Efficacy and Safety of Zoledronic Acid in Patients With Bone Metastases of Any Solid Tumors or Multiple Myeloma | July 2005 | |
| NCT00219271 | Completed | Phase 4 | Effect Of Zoledronic Acid On Circulating And Bone Marrow-Residing Prostate Cancer Cells In Patients With Clinically Localized Prostate Cancer | September 2003 | September 2009 |
| NCT00003884 | Completed | Phase 3 | Zoledronate in Treating Patients With Solid Tumors That Have Spread to the Bone | August 1998 | January 2001 |
| NCT00004928 | Completed | Phase 1 | Calcitriol and Zoledronate in Treating Patients With Progressive Prostate Cancer | October 1999 | October 2004 |
| NCT00022087 | Completed | Phase 3 | Zoledronate, Calcium, and Vitamin D in Preventing Bone Loss in Women Receiving Adjuvant Chemotherapy for Breast Cancer | December 2001 | February 2009 |
| NCT00029224 | Completed | Phase 4 | Treatment With Zoledronic Acid in Patients With Breast Cancer, Multiple Myeloma, and Prostate Cancer With Cancer Related Bone Lesions | October 2001 | November 2002 |
| NCT00033332 | Completed | Phase 3 | Dexamethasone With or Without Thalidomide in Treating Patients With Newly Diagnosed Multiple Myeloma | April 2002 | June 2006 |
| NCT00039104 | Completed | Phase 2 | Zoledronate and BMS-275291 in Treating Patients With Prostate Cancer | April 2002 | |
| NCT00046254 | Completed | Phase 3 | Evaluating the Ability of Zoledronic Acid to Reduce the Rate of Subsequent Osteoporotic Fractures After a Hip Fracture | February 2002 | February 2007 |
| NCT00049452 | Completed | Phase 3 | Zoledronate in Preventing Bone Loss in Premenopausal Women Receiving Chemotherapy After Surgery For Early Stage Breast Cancer | December 2001 | August 2008 |
| NCT00049829 | Completed | Phase 3 | HORIZON-PFT: Pivotal Fracture Trial | January 2002 | |
| NCT00558272 | Completed | Phase 2 | Study to Evaluate the Safety and Effects AZD0530 on Prostate and Breast Cancer Subjects With Metastatic Bone Disease | February 2008 | August 2012 |
| NCT00566618 | Completed | Phase 1/Phase 2 | Dasatinib in Combination With Zoledronic Acid for the Treatment of Breast Cancer With Bone Metastasis | November 1, 2007 | November 17, 2020 |
| NCT00577642 | Completed | Phase 2 | Bone Marker Assessment of Multiple Myeloma Patients Treated With Aminobisphosphonates | October 2007 | December 2012 |
| NCT00580047 | Completed | N/A | Effects of Zoledronic Acid Versus Alendronate on Bone Loss After Kidney and Kidney/Pancreas Transplants | December 1, 2003 | July 29, 2014 |
| NCT00588913 | Completed | Phase 1/Phase 2 | Adoptive Immunotherapy, Aldesleukin, and Zoledronate in Treating Patients With Stage IV Kidney Cancer and Lung Metastases | January 2006 | August 2009 |
| NCT00622505 | Completed | Phase 4 | Zoledronic Acid Treatment (Every 4 or 12 Weeks) to Prevent Skeletal Complications in Advanced Multiple Myeloma Participants | November 7, 2007 | April 3, 2012 |
| NCT00636740 | Completed | Phase 2 | Multi-Center Phase II Study to Compare MER-101 20mg Tablets to Intravenous Zometa 4mg in Male Bisphosphonate-Naive, Hormone Refractory Prostate Cancer Patients | February 2008 | February 2009 |
| NCT00685646 | Completed | Phase 3 | Androgen Blockade Therapy With or Without Zoledronic Acid in Treating Patients With Prostate Cancer and Bone Metastases | May 2008 | January 2014 |
| NCT00718861 | Completed | Phase 3 | 3 yr Efficacy & Safety Study of Zoledronic Acid in Post-menopausal Women With Osteoporosis Treated With Zol Acid for 6 Yrs | May 2008 | April 2013 |
| NCT00740129 | Completed | Phase 4 | Re-treatment of Participants With Paget's Disease Using Zoledronic Acid | October 21, 2008 | March 14, 2011 |
| NCT00741377 | Completed | Phase 1 | A Study to Assess BHQ880 in Combination With Zoledronic Acid in Relapsed or Refractory Myeloma Patients | January 2009 | December 2011 |
| NCT00742924 | Completed | Phase 1 | Zoledronic Acid and Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma | August 2008 | |
| NCT00745485 | Completed | Phase 4 | Feasibility of Doctors' Rooms-based Infusion of Zoledronic Acid | August 2008 | |
| NCT00760370 | Completed | Phase 2 | Comparison of Zometa Retention and Effect in Multiple Myeloma and Breast Cancer | December 2008 | December 2011 |
| NCT00774020 | Completed | Phase 4 | Efficacy and Safety of Single Dose of 5 mg Zoledronic Acid in Chinese Patients With Paget's Disease of Bone (PDB) | October 30, 2008 | January 14, 2011 |
| NCT00795483 | Completed | Phase 4 | Efficacy And Security Of Annual And Biennial Zoledronic Acid For Osteoporosis Treatment In An HIV-Infected Patients' Cohort | November 2009 | November 2011 |
| NCT00798473 | Completed | Phase 3 | Zoledronate for Osteopenia in Pediatric Crohn's | September 2004 | November 2008 |
| NCT00799266 | Completed | Phase 3 | An Efficacy and Safety Trial of Intravenous Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids | December 4, 2008 | March 5, 2018 |
| NCT00807963 | Completed | Phase 1 | Pharmacokinetic, Safety and Tolerability Study of SC Administered Bisphosphonate With rHuPH20 vs Bisphosphonate Alone | December 2008 | September 21, 2009 |
| NCT00869206 | Completed | Phase 3 | Zoledronic Acid in Treating Patients With Metastatic Breast Cancer, Metastatic Prostate Cancer, or Multiple Myeloma With Bone Involvement | March 2009 | January 2017 |
| NCT00879034 | Completed | Phase 2 | A Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria | March 2009 | April 2009 |
| NCT00885326 | Completed | Phase 1 | N2007-02:Bevacizumab,Cyclophosphamide,& Zoledronic Acid in Patients W/ Recurrent or Refractory High-Risk Neuroblastoma | December 2009 | December 2019 |
| NCT00896532 | Completed | Phase 2 | Romosozumab (AMG 785) in Postmenopausal Women With Low Bone Mineral Density | June 3, 2009 | February 18, 2016 |
| NCT00903162 | Completed | Phase 2 | Extended Endocrine Therapy for Premenopausal Women With Breast Cancer | May 2009 | September 2014 |
| NCT00909961 | Completed | Phase 3 | A Trial Evaluating the Effects of Zoledronic Acid 5 mg Infusion on Bone Mineral Density (BMD) in Postmenopausal Osteoporosis (PMO) Patients Between the Ages of 50 and 65 Years | November 2009 | December 16, 2011 |
| NCT00927186 | Completed | Phase 4 | Effects of Teriparatide or Zoledronic Acid Treatment on Bone in Postmenopausal Osteoporotic Women | July 2009 | April 2012 |
| NCT00972959 | Completed | Phase 2 | Effect of Combination of Bortezomib/Dexamethasone/Zoledronic Acid on Bone Disease in Patients With Multiple Myeloma Relapsed After 1-3 Prior Lines of Therapy | July 2009 | May 2013 |
| NCT00982124 | Completed | Phase 3 | An Efficacy and Safety Trial of Intravenous Zoledronic Acid in Infants Less Than One Year of Age, With Severe Osteogenesis Imperfecta | October 2007 | April 2016 |
| NCT00984893 | Completed | Intra-venous Zoledronic Acid Once Yearly | November 2008 | April 2014 | |
| NCT00987636 | Completed | Phase 3 | Study in Localized and Disseminated Ewing Sarcoma | October 1, 2009 | March 31, 2019 |
| NCT01006395 | Completed | Phase 2/Phase 3 | Prevention of Micro-architectural Bone Decay in Males With Non-metastatic Prostate Cancer Receiving Androgen Deprivation Therapy (ADT) | January 2011 | April 2019 |
| NCT01062503 | Completed | Duration of Suppression of Bone Turnover Following Treatment With Zoledronic Acid in Men With Metastatic CRPC | January 2010 | June 2014 | |
| NCT01087008 | Completed | Phase 4 | Zoledronic Acid in Patients With Multiple Myeloma and Asymptomatic Biochemical Relapse | April 2010 | June 5, 2013 |
| NCT01099436 | Completed | Phase 3 | Neo-Adjuvant Chemotherapy (TAC) With or Without Zoledronic Acid in Treating HER2-negative Breast Cancer Patients | April 2010 | September 2013 |
| NCT01129336 | Completed | Phase 4 | Effect of Zoledronic Acid as Anti-Cancer Treatment in Metastatic Breast Cancer Patients | June 2010 | August 2012 |
| NCT01153425 | Completed | Phase 4 | µMRI of Therapeutic Intervention in Postmenopausal Osteoporosis | July 2008 | December 2012 |
| NCT01194440 | Completed | Phase 2 | Zoledronic Acid in Aromatase Inhibitor Induced Musculoskeletal Symptoms | February 2011 | January 2014 |
| NCT01197300 | Completed | Phase 3 | 1 Year Open-label Extension to CZOL446H2337 Safety and Efficacy Trial of Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids | October 25, 2010 | February 27, 2019 |
| NCT01218035 | Completed | Phase 4 | Efficacy of Zoledronic Acid in Enhancement of Early Stability of Cementless Primary Hip Prosthesis | May 2007 | June 2011 |
| NCT01228318 | Completed | Phase 2 | Bone Loss and Immune Reconstitution in HIV/AIDS (BLIR-HIV) | January 2011 | April 13, 2017 |
| NCT01234129 | Completed | Stem Cell Transplant and Zoledronic Acid Improve Outcome in Previously Untreated Patients With Multiple Myeloma | June 2002 | December 2009 | |
| NCT01267279 | Completed | Phase 4 | Effect of Zoledronic Acid on Femoral Bone Loss Following Total Hip Arthroplasty | January 2005 | December 2014 |
| NCT01341262 | Completed | Phase 2 | THAL-DEX Incorporated Into Double PBSC Autotransplantation for Untreated Multiple Myeloma (MM) | March 2002 | January 2009 |
| NCT01344967 | Completed | Phase 2/Phase 3 | Suppression of Bone Turnover Following Treatment With Zoledronic Acid in Patients With Metastatic Breast Cancer: Duration of Effect | February 2009 | December 2011 |
| NCT01345019 | Completed | Phase 3 | Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma | May 17, 2012 | March 29, 2019 |
| NCT01572545 | Completed | N/A | Comparative Effect of Zoledronic Acid Versus Denosumab on Serum Sclerostin of Postmenopausal Women With Low Bone Mass | April 2012 | January 2013 |
| NCT01642901 | Completed | Phase 3 | Zoledronic Acid in Acute Spinal Cord Injury | September 2012 | March 2018 |
| NCT01671774 | Completed | Phase 1 | Safety and Activity of IMAB362 in Combination With Zoledronic Acid and Interleukin-2 in CLDN18.2-positive Gastric Cancer | October 16, 2012 | October 13, 2014 |
| NCT01675089 | Completed | Phase 4 | Zoledronic Acid to Prevent Bone Loss After Kidney Transplantation | July 2012 | May 2014 |
| NCT01721993 | Completed | Phase 1 | Open Label Dose Escalation Phase I Study to Investigate the Safety and Pharmacokinetics of T121E01F and T121E02F in Healthy Postmenopausal Women | January 2013 | August 2014 |
| NCT01732770 | Completed | Phase 4 | Safety and Efficacy Study to Evaluate Denosumab Compared With Zoledronic Acid in Postmenopausal Women With Osteoporosis | November 7, 2012 | January 7, 2015 |
| NCT01907880 | Completed | Phase 4 | The ODYSSEY TRIAL Phase IV Trial Evaluating the Palliative Benefit of Pamidronate or Zoledronic Acid in Breast Cancer | August 2012 | January 2016 |
| NCT01951586 | Completed | Phase 2 | Denosumab in Combination With Chemotherapy as First-line Treatment of Metastatic Non-small Cell Lung Cancer | December 31, 2013 | November 28, 2017 |
| NCT02042872 | Completed | Phase 4 | Zoledronic Acid Administration in Acute Spinal Cord Injury | May 2006 | July 2012 |
| NCT02176382 | Completed | Phase 4 | Denosumab and Teriparatide Study (DATA-HD and DATA-EX) | August 2014 | February 2020 |
| NCT02286830 | Completed | Phase 4 | Prolonged Protection From Bone Disease in Multiple Myeloma | January 2015 | February 16, 2023 |
| NCT02325414 | Completed | Phase 2 | Prevention of Bone Loss After Acute SCI by Zoledronic Acid | February 2015 | August 25, 2020 |
| NCT02499237 | Completed | Phase 4 | Zoledronic Acid to Maintain Bone Mass After Denosumab Discontinuation | July 2015 | November 26, 2018 |
| NCT02589600 | Completed | Phase 4 | Zoledronic Acid for Osteoporotic Fracture Prevention (ZEST II) | January 2016 | June 22, 2022 |
| NCT02632916 | Completed | Phase 2 | Denosumab for the Treatment of Osteoporosis in Children: A Pilot Study | August 2016 | February 3, 2020 |
| NCT02753283 | Completed | Phase 4 | Preventing Osteoporosis Using Denosumab | June 2016 | August 2023 |
| NCT02784652 | Completed | Phase 2 | Efficacy of Radiotherapy in Combination With Zoledronic Acid in Bone Metastasis Patients With Gastrointestinal Tumors | June 2014 | February 28, 2017 |
| NCT02808988 | Completed | Phase 4 | Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis | October 2013 | November 2015 |
| NCT03087851 | Completed | Phase 4 | Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis | March 13, 2017 | August 1, 2020 |
| NCT03289338 | Completed | Phase 2/Phase 3 | Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus | June 1, 2016 | December 31, 2018 |
| NCT03301285 | Completed | Efficacy of Zoledronic Acid in Osteoporosis of Children With Multiple Disabilities | January 1, 2017 | March 31, 2017 | |
| NCT03396315 | Completed | Phase 2 | Bisphosphonates for Prevention of Post-Denosumab Bone Loss | January 29, 2018 | June 9, 2023 |
| NCT03424239 | Completed | Phase 4 | Pilot Study for Zoledronic Acid to Prevent Bone Loss After Bariatric Surgery | August 1, 2018 | January 1, 2020 |
| NCT03862833 | Completed | Phase 1 | Zoledronic Acid in Combination With Interleukin-2 to Expand Vγ9Vδ2 T Cells After T-replete Haplo-identical Allotransplant | May 7, 2019 | August 29, 2023 |
| NCT03868033 | Completed | Phase 4 | Denosumab Sequential Therapy | April 12, 2019 | December 31, 2023 |
| NCT04736693 | Completed | Replication of the HORIZON Pivotal Fracture Trial in Healthcare Claims Data | September 22, 2020 | February 18, 2021 | |
| NCT00237146 | Completed | Phase 4 | Study to Evaluate Zoledronic Acid on Quality of Life and Skeletal-related Events as Adjuvant Treatment in Patients With Hormone-naïve Prostate Cancer and Bone Metastasis Who Have Undergone Orchiectomy | November 2003 | March 2008 |
| NCT00237159 | Completed | Phase 4 | Effect of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastasis | October 2002 | |
| NCT00241111 | Completed | Phase 4 | Assessment of the Efficacy, Tolerability and Pharmaco-economic Impact of Zoledronic Acid Treatment in Prostate Cancer With Bone Metastasis | September 2003 | |
| NCT00242554 | Completed | Phase 4 | Open-label Phase IV Clinical Trial to Evaluate the Safety and Tolerability of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastases | October 2002 | |
| NCT00242567 | Completed | Phase 3 | Study of Zoledronic Acid for Patients With Hormone-sensitive Bone Metastases From Prostate Cancer | December 2005 | January 2012 |
| NCT00263484 | Completed | Phase 2 | Higher Frequency Zoledronic Acid in the Treatment of Multiple Myeloma | December 2005 | October 2010 |
| NCT00264420 | Completed | Phase 1 | Safety and Efficacy Study of Concomitant Radiotherapy and Zoledronic Acid for Bone Metastases Palliation | December 2005 | March 2007 |
| NCT00287261 | Completed | Phase 2 | A Trial of Zoledronic Acid in Patients With Myelofibrosis With Myeloid Metaplasia (MMM) | February 2006 | March 2008 |
| NCT00295646 | Completed | Phase 3 | Tamoxifen Versus Anastrozole, Alone or in Combination With Zoledronic Acid | June 1999 | June 26, 2018 |
| NCT00295867 | Completed | Phase 2 | Zoledronate in Treating Bone Marrow Micrometastases in Women With Stage I, Stage II, or Stage III Breast Cancer | November 3, 2004 | December 2013 |
| NCT00297830 | Completed | Phase 2/Phase 3 | Zoledronic Acid Versus Alendronate for Prevention of Bone Loss After Organ Transplantation | November 2005 | January 2014 |
| NCT00305695 | Completed | Phase 2 | Zoledronate or Observation in Maintaining Bone Mineral Density in Patients Who Are Undergoing Surgery to Remove Both Ovaries | November 28, 2005 | |
| NCT00320710 | Completed | Phase 3 | Continued Efficacy and Safety of Zoledronic Acid (q 4 Wks vs. q 12 Wks) in the 2nd Year of Treatment in Patients With Bone Metastases From Breast Cancer | February 2006 | July 2013 |
| NCT00321464 | Completed | Phase 3 | A Study Comparing Denosumab vs. Zoledronic Acid for the Treatment of Bone Metastases in Breast Cancer Subjects. | April 1, 2006 | April 4, 2012 |
| NCT00321620 | Completed | Phase 3 | Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Men With Hormone-refractory Prostate Cancer | April 1, 2006 | February 24, 2012 |
| NCT00321932 | Completed | Phase 2 | Zoledronic Acid in Preventing Osteoporosis in Patients Undergoing Donor Stem Cell Transplant | July 2005 | March 2012 |
| NCT00329797 | Completed | Phase 3 | Zoledronate in Preventing Osteoporosis and Bone Fractures in Patients With Locally Advanced Nonmetastatic Prostate Cancer Undergoing Radiation Therapy and Hormone Therapy | March 2006 | November 2014 |
| NCT00330759 | Completed | Phase 3 | Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma. | June 1, 2006 | October 1, 2011 |
| NCT00332709 | Completed | Phase 3 | Safety/Efficacy of Letrozole Monotherapy or in Combination With Zoledronic Acid as Extended Adjuvant Treatment of Postmenopausal Patients With Primary Breast Cancer | January 2006 | August 2010 |
| NCT00334139 | Completed | Phase 4 | Effect of Zoledronic Acid on Bone Metabolism in Patients With Bone Metastasis and Prostate or Breast Cancer | May 2006 | July 2009 |
| NCT00346242 | Completed | Phase 4 | Evaluation of Efficacy of Zoledronic Acid in Patients With Haemoglobin Syndromes (Thalassemia and Sicle Cell Anaemia) and Risk of Skeletal Events | March 2004 | |
| NCT00352846 | Completed | Phase 3 | Effect of Zoledronic Acid on Chemotherapy Induced Bone Loss | January 2006 | September 2011 |
| NCT00361595 | Completed | N/A | Intervenous (IV) Zoledronic Acid After Forteo in Postmenopausal Women | August 2006 | April 2008 |
| NCT00365105 | Completed | Phase 3 | Zoledronate, Vitamin D, and Calcium With or Without Strontium 89 or Samarium 153 in Preventing or Delaying Bone Problems in Patients With Bone Metastases From Prostate Cancer, Lung Cancer, or Breast Cancer | July 11, 2006 | February 27, 2017 |
| NCT00375427 | Completed | Phase 3 | Safety and Efficacy of Zoledronic Acid in Patients With Breast Cancer With Metastatic Bone Lesions | February 2006 | |
| NCT00375505 | Completed | Phase 3 | The Safety and Efficacy of Zoledronic Acid in the Prevention of Cancer Therapy Induced Bone Loss | October 2005 | May 2014 |
| NCT00375648 | Completed | Phase 3 | Efficacy and Safety of Zoledronic Acid in the Treatment of Bone Metastases-related Pain in Patients With Prostate Cancer | June 2005 | |
| NCT00376740 | Completed | Phase 3 | Effectiveness of Zoledronic Acid in the Prevention of Osteoporosis in Early Breast Cancer Patients Receiving Letrozole | September 2005 | |
| NCT00391690 | Completed | Phase 4 | Evaluation of Bone Markers as Diagnostic Tools for Early Detection of Bone Metastases in Patients With High Risk Prostate Cancer | February 2006 | |
| NCT00415779 | Completed | Phase 1 | ZANTE: Zometa and Taxotere in Hormone Refractory Prostate Cancer | July 2006 | July 2009 |
| NCT00424983 | Completed | Phase 1 | Study of Zoledronic Acid Administered Monthly Versus Every 3 Months in Multiple Myeloma and Breast Cancer Patients Who Were Treated With Zoledronic Acid the Prior Year | November 2006 | November 2009 |
| NCT00431444 | Completed | Phase 4 | Effects of Zoledronic Acid and Raloxifene on Bone Turnover Markers in Postmenopausal Women With Low Bone Mineral Density | January 2007 | July 2008 |
| NCT00432458 | Completed | Phase 3 | Zoledronate With or Without Thalidomide in Treating Patients With Early Stage Multiple Myeloma | July 2003 | April 2012 |
| NCT00434317 | Completed | Phase 4 | Assessment of Pain and Quality of Life in Breast and Prostate Cancer Patients With Bone Metastases | August 2005 | |
| NCT00434447 | Completed | Phase 4 | Long Term Efficacy and Safety of Zoledronic Acid Treatment in Patients With Bone Metastases | December 2006 | |
| NCT00436917 | Completed | N/A | Zoledronate in Treating Osteopenia or Osteoporosis in Postmenopausal Women Receiving Letrozole for Stage I, Stage II, or Stage IIIA Primary Breast Cancer | April 2006 | May 9, 2016 |
| NCT00439244 | Completed | Phase 3 | Efficacy Study of Zoledronic Acid and Teriparatide Combination Therapy in Women With Osteoporosis | December 2006 | February 2009 |
| NCT00482378 | Completed | Phase 1/Phase 2 | Samarium Sm 153 Lexidronam Pentasodium Combined With Zoledronic Acid or Pamidronate in Treating Patients With Relapsed or Refractory Multiple Myeloma and Bone Pain | March 21, 2005 | December 2, 2008 |
| NCT00512993 | Completed | Phase 3 | Postoperative Use of Zoledronic Acid in Breast Cancer Patients After Neoadjuvant Chemotherapy | December 2004 | November 2013 |
| NCT00520052 | Completed | N/A | Frequency of Zoledronic Acid to Prevent Further Bone Loss in Osteoporotic Patients Requiring Androgen Deprivation Therapy for Prostate Cancer | August 2003 | August 2005 |
| NCT00524849 | Completed | Phase 2/Phase 3 | Zometa and Circulating Vascular Endothelial Growth Factor (VEGF) in Breast Cancer Patients With Bone Metastasis | November 2006 | January 2010 |
| NCT00554918 | Completed | Phase 2 | Docetaxel and Prednisolone With or Without Zoledronic Acid and/or Strontium Chloride Sr 89 in Treating Patients With Prostate Cancer Metastatic to Bone That Has Not Responded to Hormone Therapy | February 2005 | June 2013 |
| NCT00556374 | Completed | Phase 3 | Study to Determine Treatment Effects of Denosumab in Patients With Breast Cancer Receiving Aromatase Inhibitor Therapy | December 18, 2006 | July 26, 2022 |
| NCT04085419 | Enrolling by invitation | Phase 4 | Osteoporosis in Primary Hyperparathyroidism | May 8, 2019 | May 2023 |
| NCT06221072 | Not yet recruiting | Phase 3 | A Study to Assess the Prevention of Bone-related Events in Patients With Bone Metastases From Malignant Solid Tumors Treated With JMT103 Compared to Zoledronic Acid | April 5, 2024 | May 31, 2028 |
| NCT06374459 | Not yet recruiting | Phase 1/Phase 2 | Zunsemetinib in Combination With Capecitabine in Patients With Hormone Receptor-Positive and HER2-Negative Metastatic Breast Cancer With Bone Metastasis | July 31, 2024 | November 30, 2031 |
| NCT06135298 | Recruiting | Phase 4 | FARE Augmentation of Proximal Femoral Fractures With CaS/HA and Systemic ZA | December 1, 2023 | June 1, 2025 |
| NCT06051344 | Recruiting | Phase 4 | Effect of Zoledronic Acid in Primary Knee Osteoarthritis | January 1, 2023 | December 31, 2023 |
| NCT05058976 | Recruiting | Phase 4 | Romosozumab Use to Build Skeletal Integrity | September 15, 2021 | September 2027 |
| NCT05866172 | Recruiting | Phase 3 | HAIC Combined Withzoledronic Acid for the Prevention of Bone Metastases in Advanced HCC | May 10, 2023 | June 1, 2025 |
| NCT04303026 | Recruiting | Phase 3 | The Effect of Zoledronic Acid on Patients With Osteoarthritis of the Hip | March 2, 2020 | June 30, 2024 |
| NCT05106517 | Recruiting | Phase 2/Phase 3 | Denosumab vs Zoledronic Acid and Osteoporotic Compression Fracture | September 8, 2021 | March 11, 2023 |
| NCT03295981 | Recruiting | Phase 3 | Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone | May 3, 2018 | January 2026 |
| NCT04725422 | Recruiting | CHronic Nonbacterial Osteomyelitis International Registry (CHOIR) | August 1, 2018 | August 2050 | |
| NCT03073785 | Recruiting | Phase 2 | Hypofractionated Stereotactic Body Radiation & Fluorouracil or Capecitabine for Locally Advanced Pancreatic Cancer | September 16, 2016 | December 2027 |
| NCT02123264 | Terminated | Phase 3 | Zoledronic Acid in Rheumatoid Arthritis | May 2014 | June 2018 |
| NCT01802658 | Terminated | Phase 3 | Bone Demineralization Lesions in the Injured Marrow: Efficacy and Tolerability of Administration Early and Repeated the Zoledronic Acid. Comparative Study, Prospective, Double-blind Controlled (DBMZol) | November 2012 | December 2016 |
| NCT00258258 | Terminated | Phase 1 | Paricalcitol and Zoledronate in Treating Patients With Relapsed or Refractory Multiple Myeloma or Other Plasma Cell Disorders | August 2005 | |
| NCT00258765 | Terminated | Phase 2 | Adjuvant Docetaxel-Zoledronic Acid in High-risk Early Prostate Cancer Following Prostatectomy. | May 2006 | |
| NCT00265200 | Terminated | Phase 2 | Using TRAP to Evaluate the Effect of Zometa on Bone Metastasis Due to Lung Cancer | February 2005 | December 2010 |
| NCT00216151 | Terminated | Phase 2 | Zoledronic Acid in the Management of Patients With Asymptomatic/Early Stage Multiple Myeloma | June 2005 | March 2007 |
| NCT00099177 | Terminated | Phase 3 | A Study to Assess the Efficacy of Intravenous/Oral Bondronat (Ibandronate) in Patients With Metastatic Bone Disease Experiencing Moderate to Severe Pain | August 2005 | December 2007 |
| NCT00844480 | Terminated | Phase 2 | Efficacy and Safety of Zoledronic Acid in Acute Spinal Cord Injury: Prevention of Bone Loss | March 2010 | January 2016 |
| NCT00226954 | Terminated | Phase 2 | Zoledronic Acid With Intermittent Hormonal Therapy in Patients With Prostate Cancer | March 2003 | February 2009 |
| NCT00889590 | Terminated | Phase 2 | Adjuvant Zoledronic Acid in High Risk Giant Cell Tumour of Bone (GCT) | December 2008 | July 2015 |
| NCT00892242 | Terminated | Phase 1 | Perioperative Treatment With Zoledronic Acid in Patients With Resectable Pancreas Cancer | December 2009 | April 2013 |
| NCT00333229 | Terminated | Phase 4 | A Study of Zoledronic Acid in the Prevention of Cancer Therapy-induced Bone Loss | March 2006 | December 2013 |
| NCT00966992 | Terminated | Phase 2 | Study of Zoledronic Acid Versus Observation on Bone Mineral Density and Incidence of Micrometastasis in Women Undergoing Pelvic Radiation for Cervical Cancer | August 2009 | March 2010 |
| NCT00130494 | Terminated | Phase 3 | Zoledronic Acid Administration to Metastatic Breast Cancer Patients With Non-symptomatic Bone Lesions | August 29, 2002 | October 22, 2007 |
| NCT00372710 | Terminated | Phase 3 | Safety/Efficacy of Intravenous Zoledronic Acid When Added to Standard Therapies in Patients With Breast Cancer and Metastatic Bone Lesions | August 2002 | |
| NCT01004510 | Terminated | Phase 2 | Zometa Adjuvant Treatment of Malignant Pleural Effusion Due To Non-Small Cell Lung Cancer | November 2009 | April 2011 |
| NCT00391950 | Terminated | Phase 3 | Maintaining Bone Strength in Men With Prostate Cancer | October 2006 | |
| NCT00215943 | Terminated | Phase 3 | Phase III Randomized Trial of Thalidomide/Dexamethasone Versus Vincristine+Adriamycin+Dexamethasone (VAD) | June 2003 | August 2012 |
| NCT01166178 | Terminated | Phase 3 | Zoledronic Acid in MS-patients With Osteoporosis | October 2010 | June 2012 |
| NCT00458796 | Terminated | N/A | Comparison of Two Schedules of Zoledronic Acid in Treating Patients With Breast Cancer That Has Spread to the Bone | March 2006 | |
| NCT00171925 | Terminated | Phase 3 | Therapy With Zoledronic Acid in Patients With Multiple Myeloma Stage I | August 2000 | November 2008 |
| NCT00099203 | Terminated | Phase 3 | A Study to Assess the Efficacy of Intravenous Bondronat (Ibandronate) in Patients With Malignant and Painful Bone Disease | July 2005 | December 2007 |
| NCT00058188 | Terminated | Phase 3 | Zolendronate for the Prevention of Bone Loss in Men w/ Prostate CA on Long-Term Androgen Deprivation | March 2003 | November 2008 |
| NCT00005073 | Terminated | Phase 3 | Zoledronate Plus Standard Therapy Compared With Placebo Plus Standard Therapy to Prevent Bone Metastases in Patients With Recurrent Prostate Cancer That Has No Symptoms | September 1999 | March 2003 |
| NCT01404702 | Terminated | Phase 1 | Pilot Study of Zoledronic Acid and Interleukin-2 for Refractory Pediatric Neuroblastoma | August 2011 | August 2014 |
| NCT01409811 | Terminated | N/A | Biomarkers in Tissue Samples From Patients With Newly Diagnosed Breast Cancer Treated With Zoledronic Acid | September 14, 2012 | February 2015 |
| NCT00582790 | Terminated | Phase 2 | Study of IL2 in Combination With Zoledronic Acid in Patients With Kidney Cancer | August 2003 | September 2008 |
| NCT01426555 | Terminated | Phase 2/Phase 3 | FES-Rowing Versus Zoledronic Acid to Improve Bone Health in Spinal Cord Injury (SCI) | February 2011 | February 2015 |
| NCT01679080 | Terminated | Phase 2 | The Effect of Treatment With Teriparatide and Zoledronic Acid in Patients With Osteogenesis Imperfecta | November 2012 | June 1, 2021 |
| NCT00326820 | Unknown status | Phase 3 | Ibandronate or Zoledronate in Treating Patients With Newly Diagnosed Bone Metastases From Breast Cancer | January 2006 | October 2015 |
| NCT04115397 | Unknown status | Phase 4 | Bisphosphonates for the Treatment of Seropositive Musculoskeletal Complaints | January 2020 | December 2022 |
| NCT04742010 | Unknown status | Phase 2 | Zoledronic Acid for Prevention of Bone Loss After BAriatric Surgery (ZABAS) | February 20, 2021 | June 2024 |
| NCT01310465 | Unknown status | Phase 4 | The Effect of Zoledronic Acid to Bone Fusion and Bone Metabolism of Patients With Lumbar Degenerative Disease After Lumbar Interbody Fusion | January 2011 | April 2012 |
| NCT04652128 | Unknown status | N/A | Effect of Zoledronic Acid on Prevention of Bone Loss in Acute Phase First-ever Stroke Patients | July 15, 2019 | February 2023 |
| NCT02595138 | Unknown status | Phase 3 | Zoledronic Acid as Adjuvant Treatment of Triple-negative Breast Cancer | October 2015 | December 2023 |
| NCT02622607 | Unknown status | Phase 3 | Preventive Effects of Zoledronic Acid on Bone Metastasis in Patients With Stage IIIB and IV Lung Cancer | January 2013 | March 2018 |
| NCT03336983 | Unknown status | Phase 2 | Luteinizing Hormone-releasing Hormone Analogue and Enzalutamide +/- Zoledronic Acid in Prostate Cancer Patients | December 1, 2017 | December 1, 2023 |
| NCT01016093 | Unknown status | Phase 2/Phase 3 | Zoledronic Acid for the Prevention of Bone Loss Post-bone Marrow Transplantation for Thalassemia Major Patients | November 2009 | December 2011 |
| NCT04034199 | Unknown status | Phase 3 | Treating Idiopathic Inflammatory Myopathies Related Reduced Bone Mineral Density With Denosumab or Zoledronic Acid | August 15, 2019 | March 31, 2021 |
| NCT02721940 | Unknown status | N/A | Mononuclear Cells, Platelets and Zoledronic Acid for Preventing Collapse of the Femoral Head in Osteonecrosis | February 2012 | May 2016 |
| NCT00691236 | Unknown status | Phase 2/Phase 3 | Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma | May 2008 | August 2013 |
| NCT04045522 | Unknown status | Study on Bisphosphonates Targeting Triple-negative Breast Cancer | September 1, 2019 | August 31, 2022 | |
| NCT03932071 | Unknown status | Phase 4 | Zoledronic Acid in Decrease the Lung Metastatic Rate of Osteosarcoma | January 1, 2017 | January 1, 2023 |
| NCT03169192 | Unknown status | Diagnosis of Osteogenesis Imperfecta in Children | June 1, 2017 | March 1, 2019 | |
| NCT01788176 | Unknown status | Phase 2 | The Use of Zoledronic Acid to Complex Regional Pain Syndrome | December 2013 | December 2016 |
| NCT00072020 | Unknown status | Phase 3 | Chemotherapy and/or Hormone Therapy With or Without Zoledronate in Treating Women With Stage II or Stage III Breast Cancer | August 2003 | |
| NCT02480634 | Unknown status | Phase 4 | Zoledronic Acid Combined Radiotherapy for Bone Metastasis of Non-small Cell Lung Cancer | June 2019 | December 2022 |
| NCT03735537 | Unknown status | Phase 4 | Treatment of Osteogenesis Imperfecta With Parathyroid Hormone and Zoledronic Acid | November 1, 2016 | April 1, 2023 |
| NCT00912938 | Unknown status | Phase 4 | Evaluate the Relationship of Bone Remodeling Markers for Skeletal Complications in Metastatic Breast Cancer Patients | December 2007 | December 2010 |
| NCT04597931 | Unknown status | Phase 4 | Evaluation of Romosozumab vs. Zoledronic Acid Effect in Patients With Spinal Cord Injury and Low Bone Mineral Density | November 1, 2020 | November 15, 2023 |
| NCT00781261 | Unknown status | Phase 2 | Osteonecrosis of the Hip and Bisphosphonate Treatment | August 2009 | December 2013 |
| NCT00873808 | Withdrawn | S0307A, Long-Term Bone Quality in Women With Breast Cancer Enrolled on Clinical Trial SWOG-S0307 | October 2008 | February 2010 | |
| NCT00639392 | Withdrawn | Phase 1/Phase 2 | Phase 1 Study of Zoledronic Acid in Sickle Cell Disease | June 2007 | May 2008 |
| NCT02069340 | Withdrawn | N/A | Genetics in Predicting Risk of Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid | June 2016 | June 2021 |
| NCT00242528 | Withdrawn | Phase 4 | Open-label Study, to Evaluate the Safety and Tolerability of Zoledronic Acid in Patients With Bone Lesions Secondary to Multiple Myeloma. | April 2004 | |
| NCT02451462 | Withdrawn | N/A | Pilot Trial of Zoledronic Acid to Prevent Bone Loss in Hematopoietic Cell Transplant Recipients | September 2015 | September 2018 |
| NCT01702415 | Withdrawn | Phase 4 | Zoledronic Acid in Cystic Fibrosis | October 2013 | December 2015 |
| NCT00477217 | Withdrawn | Phase 2 | Zoledronic Acid Treatment of Spontaneous Osteonecrosis of the Knee | January 2008 | May 2009 |
| NCT02632903 | Withdrawn | Phase 2 | Intravenous Zoledronic Acid for the Treatment of Osteoporosis and Osteonecrosis in Children With Leukemia: A Pilot Study | October 2016 | August 20, 2018 |